- Icons are born in games between Liverpool and Manchester United
- Diego Forlan and Andrea Dossena have both scored in the derby
- Sportsmail has looked back at the tie's unlikeliest match winners
Those moments that settle these contests tend to go down as famous events in Premier League history.
However, games are not always won by the most likely of sources, with goals often coming from unexpected places.
Matches in the North West derby are no different to any other encounter.
Ahead of Monday's contest, Sportsmail has looked back at the unlikeliest match winners in games between Liverpool and United.
A prolific goalscorer elsewhere, but Diego Forlan developed a reputation at Old Trafford for the rarity with which he struck home.
His other claim to fame is winning a tie against Liverpool almost singlehandedly.
Forlan hit a brace over the space of five minutes in December 2002 to win the tie at Anfield.
United fans still enthusiastically sing Forlan's name to this day, almost entirely because of his display against their bitter rivals on that December day. It will get another airing on Monday.
Diego Forlan hit a brace over the space of five minutes at Anfield in December 2002
The focus in September 2004 was all on Rio Ferdinand, who returned to action after an eight-month ban in one of the most hot-blooded games possible.
However, it was another defender that shone - Mikael Silvestre, who scored two headed goals to give his backline partner a winning return.
Having gone ahead, United were pegged back but Silvestre popped up again in the second-half to win the game.
Mikael Silvestre scored two headed goals to give Rio Ferdinand a winning return in 2004
It may feel harsh to list a forward as an unlikely goalscorer, but Ryan Babel's spell at Anfield was far from a success.
One of the best moments of his time on Merseyside came in the 76th minute of a match between United and Liverpool.
He was only introduced as a substitute five minutes prior.
Dirk Kuyt crossed low into the area and Babel only needed one touch to fire into the back of the net and send the Kop into raptures.
Dutchman Ryan Babel celebrates his goal against Manchester United in September 2008
2009 was a good year for Liverpool, as they came as close as they have to capturing the Premier League.
While they ultimately missed out, any season in which a side finishes second will include memorable moments.
One of the highlights of the campaign was undoubtedly the 4-1 victory at Old Trafford that had all the hallmarks of champions, not least Andrea Dossena's impudent lob that rounded off a majestic performance from the Reds.
Andrea Dossena (right) is congratulated by Babel after his impudent lob in March 2009
While he was something of a cult hero at Old Trafford, Park Ji-sung was not much of a goalscorer. The South Korean bagged just 19 goals in his 134 appearances for United.
However, he tended to bag when it really mattered.
March 2010 was another one of those occassions. He scored the winning goal by turning in Darren Fletcher's cross with a diving header.
South Korean cult hero Park Ji-sung scored a diving header against Liverpool in March 2010