- Hugo Lloris made incredible save with a roll on the goalline to deny Leverkusen as Spurs earned a point
- Dele Alli headed wide in the first half before Vincent Janssen clattered the ball against the cross bar
- Erik Lamela was first to the follow up and produced a scissor kick which was tipped over by Bernd Leno
- Tottenham are second in Group E with four points as leaders Monaco drew with CSKA
- Aspirin was invented by the pharmaceutical giants which founded Bayer Leverkusen but only the excellence of Hugo Lloris kept the pain at bay for Tottenham.
Lloris stood virtually redundant as Spurs totally dominated the first-half of this Champions League tie but his goal came under an onslaught after the interval.
Among them one breath-taking save to deny Javier Hernandez from close-range with the Spurs goalkeeper somehow springing across his goal, grabbing the ball and clinging on to ensure it did not cross the line as his momentum sent him rolling across the turf.
Tottenham stopper Hugo Lloris makes a sprawling save to deny Javier Hernandez whose shot evaded Kieran Trippier sliding in
The Frenchman impressed as Spurs earned a vital point and rolled over the ball on the goalline in emphatic fashion
Lloris grabs the ball after completing a stunning save which saw him roll over the line to stop Leverkusen from close range
Vincent Janssen watches on as his header evades the reach of Bernd Leno but smashes against the cross bar in the first half
Erik Lamela followed up with a scissor kick on goal but Leverkusen keeper Leno did excellently to tip the ball over the bar
Tottenham midfielder Dele Alli powers a header towards goal but failed to direct the ball on goal as it sailed wide of the post
'After more than two years here, I can only say good things about Hugo Lloris,' said manager Mauricio Pochettino. 'He is a fantastic goalkeeper, one of the best in the world and he was brilliant again.
'He is in the best moment in his career and it is important for us to have a 'keeper like him.'
Having started with such promise and purpose, Tottenham were shocked to be clinging on at the end and were happy to escape Germany with a point.
Their hopes of qualifying for the knock-out phase of the competition were also boosted by an 87th-minute equaliser for Monaco against CSKA Moscow.
Group E is shaping up to be extremely tight but Spurs are second and well set if they can find their form at Wembley, where they were beaten by Monaco in the opening fixture in September and will face Leverkusen again in a fortnight.
Pochettino will feel the pressure at this temporary home but the situation would have been far more perilous without the heroics from Lloris in the BayArena.
'We need to be pleased with the point,' said the Spurs boss. 'Bayer Leverkusen is a good team, used to playing in the Champions League. The point is important. We must be happy with that.
'We are still fighting and we need to keep fighting until the final game. It is a very competitive group and we are fighting to go into the next round with three games to play. We must believe we can go to the next round.'
Tottenham really ought to have been ahead by the interval. Vincent Janssen, starting up front, had a goal ruled in the 10th minute because Son Heung-min was a few inches offside as he darted forward onto a pass from Erik Lamela.
Son, jeered by the home crowd on his first return to the club he left last year for Spurs, pulled a ball square for Janssen but the flag was up.
Leverkusen forward Stefan Kiessling battles Tottenham midfielder Victor Wanyama as the rain poured down at the Bay Arena
Leverkusen centre back Omer Toprak passes the ball back under pressure from Tottenham's No 9 Vincent Janssen
Javier Hernandez flies through the air and screams out under the challenge of Tottenham and England left back Danny Rose
Winger Kevin Kampl loses his balances as he fails in his attempts to stop Alli who races forward with the ball
Spurs frontman Son Heung-min, on his return to Leverkusen having left in 2015, gets the better of defender Lars Bender
Lamela bravely beats fellow South American Charles Aranguiz to the ball in the air as the duo do battle in Germany
Tottenham manager Mauricio Pochettino barks orders and instructs his players from the touchline during Tuesday's clash
Tottenham's draw means they are second in Group E, a point behind leaders Monaco who drew 1-1 against CSKA Moscow
Dele Alli missed a sitter, heading wide from a perfect cross by Kieran Trippier, deputising at right-back for Kyle Walker who was rested. Alli arrived late and connected firmly, only to see the effort flash wide, a yard the wrong side of the post.
'A few days ago, at West Brom, he scored a very good goal,' said Pochettino. 'To be fresh and clinical in front of goal is not easy. It is the most difficult thing in football. The good thing is we created many chances.'
Janssen headed against the bar. Again the chance came from another fine delivery by Trippier, who was more reliable in attack then defence. Lamela hooked the rebound towards goal it was tipped over by goalkeeper Bernd Leno.
The Germans did not have a shot on target in the first-half. The best of the home team was a couple of efforts which flashed wide from outside the penalty area. 'We found out how good Tottenham were,' said Bayer Leverkusen boss Roger Schmidt, who made a tactical switch during the interval which would bring his side back into the game.
Julian Baumgartlinger came on for Hakan Calhanoglu who had a sore back, which added midfield bite and allowed Hernandez to push further forward through the centre.
Within 30 seconds, Leverkusen had seen a goal of their own disallowed. Admir Mehmedi slid the ball into an unguarded net from out wide on the right after Lloris dashed from his area to beat Hernandez to the ball, only to be tripped by the former Manchester United striker.
Alli had a busy evening as Tottenham toiled to earn a point - CLICK HERE for more from our brilliant Match Zone service
Hernandez goes to ground awkwardly as he crashes into Tottenham's Belgian centre back Jan Vertonghen at the Bay Arena
Janssen battles on with the ball just outside the area as Leverkusen defender Toprak tugs on the Dutchman's shirt
Rose and Aranguiz square up and have to be parted by referee Cuneyt Cakir as Leverkusen's Kampl lies on the ground
Leverkusen defender Jonathan Tah climbs above Lamela to hammer the ball away clear of danger with his head
Leverkusen's Switzerland international Admir Mehmedi holds off the challenge of Alli during the Champions League clash
Son spins away from Leverkusen captain Bender who sticks out a toe to stop Tottenham's South Korea international
Lloris then produced his wonder-save. Hernandez appeared certain to bury a low cross from Lars Bender and hit the target with a firm side-footer from six yards only for the Tottenham goalkeeper to hurl himself across and keep it out.
'You need a bit of luck in that kind of action,' said Lloris. 'This time I could save this goal. It's important. It's a key moment but it's not the only one. We did a great job altogether.'
Hernandez pleaded with the additional assistant referee behind the goal line. There is no goal line technology in the Champions League. It was a close call but television replays supported the decision of the Turkish official.
Without the soothing presence of Toby Alderweireld at the back, Spurs wobbled. Lloris was kept busy with saves of all kind and Danny Rose capped another strong display by diverting a volley by Hernandez over.
The Mexican slid another chance wide at the near post and Jan Vertonghen made a crucial late tackle as Stefan Kiessling threatened to break clear.For Bayer Leverkusen it was a bitter pill. For Tottenham, a vital result.