Der Spiegel will publish two different covers of the magazine with the one sold in Britain titled "Please don't go! Why Germany needs the British." It will be available at a reduced price of 2 pounds ($2.90), Spiegel said.
Spiegel Editor-in-Chief Klaus Brinkbaeumer said the magazine's cover story would contain a multitude of reasons on why the EU cannot do without Britain.
"The result is an objective but also strong, emotional - and bilingual - appeal to the country: Please don't go!" Brinkbaeumer said in a statement on Friday.
While German politicians have stayed out of the campaign in the run-up to Britain's June 23 referendum on EU membership, for fear of being seen to be bossing Britons around, Berlin is worried about losing a kindred free-market spirit in the bloc.
Spiegel said the cover story would describe the important role Britain has played in shaping the EU and analyze the consequences of a Brexit on Europe's, ability to combat terror and geo-strategic weight.
A survey from polling firm TNS for Spiegel found 79 percent of Germans wanted Britain to remain in the EU.
Just over half of respondents believed that a Brexit would have no negative impact on the Germany economy, compared to 36 percent who thought the economic situation in Europe's largest economy would deteriorate.